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Langvarige smerter behandles annerledes enn akutt smerte. Langvarige smerter behandles fileørst og fremst med tiltak og teknikker som bidrar til bedre smertemestring.Disse fremstilles ved industriell behandling av ekstrakter fra valmue eller kjemisk produksjon uavhengig av opiumråstoff, for eksempel oksykodon og fentanyl.I slutningen af 1800-tall
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